Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies worldwide with an urgent need for new diagnostic and therapeutic strategies.One major risk factor for PDAC is the pre-indication of chronic pancreatitis (CP), which represents highly inflammatory pancreatic tissue.Kallikreins (KLKs) are secreted se
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation
Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was objective response r
Using a Ladder of Seeps With Computer Decision Processes to Explore for and Evaluate Cold Seeps on the Costa Rica Active Margin
Natural seeps occur at the seafloor as loci of fluid flow where the flux of chemical compounds into the ocean supports unique biologic communities and provides access to proxy samples of deep subsurface processes.Cold seeps accomplish this LUGGAGE with minimal heat flux.While individual expertize is applied to locate seeps, such knowledge is nowher
Automated Structural Bolt Micro Looseness Monitoring Method Using Deep Learning
The detection of bolt loosening in key components of aircraft engines faces problems such as Delta Cart complex and difficult-to-establish bolt loosening mechanism models, difficulty in identifying early loosening, and difficulty in extracting signal features with nonlinear and non-stationary characteristics.Therefore, the automated structural bolt